ABSTRACT
In patients of chronic myeloid leukemia blood adrenaline, noradrenaline, dopamine and glutamate level were significantly elevated. The GABA levels were decreased along with no significant alterations in aspartate levels in these patients. In cases of acute myeloid leukemia only adrenaline and glutamate levels were enhanced with decreased GABA levels. However, plasma cortisol levels were significantly enhanced in both chronic and acute myeloid leukemia patients. These observations suggest that the circulating bioamines, cortisol and certain aminoacids level are considerably altered in chronic and acute myeloid leukemia. All these changes may possibly be attributed to the stress induced by the disease.
Subject(s)
Adolescent , Adult , Amino Acids/blood , Biogenic Amines/blood , Female , Humans , Hydrocortisone/blood , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/blood , Leukemia, Myeloid, Acute/blood , Male , Middle AgedSubject(s)
Amino Acids/blood , Animals , Brain/metabolism , Catecholamines/blood , Female , Rats , Stress, Physiological/bloodSubject(s)
Adult , Breast Neoplasms/blood , Female , Humans , Hydrocortisone/blood , Middle Aged , Neoplasm Staging , Neurotransmitter Agents/blood , Biomarkers, Tumor/bloodSubject(s)
Adult , Aged , Female , Humans , Leukocyte Count , Middle Aged , Rosette Formation , T-Lymphocytes/immunology , Uterine Cervical Neoplasms/immunologySubject(s)
Animals , Brain/metabolism , Brain Mapping , Craniocerebral Trauma/metabolism , Dogs , Serotonin/metabolismSubject(s)
Adolescent , Adult , Female , Follow-Up Studies , Histamine/metabolism , Humans , Leukemia, Myeloid/metabolism , Male , Middle AgedSubject(s)
Adolescent , Adult , Biogenic Amines/analysis , Child , Female , Humans , Male , Middle Aged , Tuberculosis, Meningeal/metabolismSubject(s)
Adolescent , Adult , Cyclic AMP/urine , Humans , Leukemia, Myeloid/urine , Leukemia, Myeloid, Acute/urine , Middle AgedSubject(s)
Acetylcholine/blood , Animals , Ascorbic Acid/pharmacology , Humans , Hydrocortisone/blood , Immobilization , Rats , Stress, Psychological/bloodSubject(s)
3',5'-Cyclic-AMP Phosphodiesterases/blood , Adult , Cyclic AMP/blood , Female , Humans , Male , Middle Aged , Neoplasms/enzymology , Postoperative PeriodSubject(s)
Animals , Female , Humans , Male , Pineal Gland/physiopathology , Rats , Stress, Psychological/physiopathology , Thyroid Gland/physiopathology , ThyroidectomySubject(s)
Animals , Colon/surgery , Dogs , Ileum/surgery , Jejunum/surgery , Kinetics , Serotonin/blood , Stomach/surgeryABSTRACT
In eighteen normal healthy volunteers, the effect of cigarette smoking, coffee drinking and alcohol consumption on adrenomedullary sympathetic function was assessed in terms of urinary VMA levels. Following the indulgence in all these social habits, urinary VMA levels are significantly increased. The maximum and minimum increase in VMA levels were recorded following coffee drinking and alcohol consumption respectively.